Mouse C-C Motif Chemokine 2, CCL2 ELI

Acts as a ligand for C-C chemokine receptor CCR2 (By similarity).

Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity).

Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity).

Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (PubMed: 29993042).

Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (PubMed: 29993042).