Mouse Cadherin-2, CDH2 ELI

Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell (PubMed: 2762814, PubMed: 11433297, PubMed: 17988630, PubMed: 9655503, PubMed: 25253890).

Cadherins may thus contribute to the sorting of heterogeneous cell types.

Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence (PubMed: 24952463).

Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (PubMed: 26750727).

CDH2 may be involved in neuronal recognition mechanism.

In hippocampal neurons, may regulate dendritic spine density.