Mouse Caspase 3, CASP3 ELI

Involved in the activation cascade of caspases responsible for apoptosis execution.

At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond.

Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain.

Cleaves and activates caspase-6, -7 and -9.

Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).

Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity).

Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed: 12124386).