Mouse Cathepsin L1, CTSL1 ELI

Thiol protease important for the overall degradation of proteins in lysosomes (Probable).

Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed: 12782676).

In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin Peptide neurotransmitter (PubMed: 12869695).

In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound Peptide ligands presented by cortical thymic epithelial cells (PubMed: 12021314).

Also mediates invariant chain processing in cortical thymic epithelial cells (PubMed: 9545226).

Major elastin-degrading enzyme at neutral pH.

Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (PubMed: 12417635).

Secreted form generates endostatin from COL18A1 (PubMed: 10716919).

Critical for cardiac morphology and function (PubMed: 11972068).

Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (PubMed: 12163394).

Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity).