Mouse CCR4-NOT transcription complex subunit 6,CNOT6 ELI

Poly(A) nuclease with 3'-5' RNase activity.

Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.

Additional complex functions may be a consequence of its influence on mRNA expression.

Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm.

In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors.

Mediates cell proliferation and cell survival and prevents cellular senescence.

{ECO:0000250|UniProtKB:Q9ULM6}.