Mouse Cdgsh Iron-sulfur Domain-containing Protein 2, CISD2 ELI

Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum.

Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca2+ stores during autophagy.

Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases.

Involved in life span control, probably via its function as regulator of autophagy (By similarity).