Mouse Cerebellin-1, CBLN1 ELI

Required for synapse integrity and synaptic plasticity.

During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses (PubMed: 16234806).

Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components (PubMed: 20395510).

On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2 (PubMed: 21410790).

NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles (PubMed: 23141067).

Required for CBLN3 export from the endoplasmic reticulum and secretion (PubMed: 17030622, PubMed: 17331201).

NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (By similarity).

Essential for long-term maintenance but not establishment of excitatory synapses (PubMed: 29691328).

Inhibits the formation and function of inhibitory GABAergic synapses in cerebellar Purkinje cells (PubMed: 24467251).

The cerebellin Peptide exerts neuromodulatory functions.

Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity).