Mouse Chemokine C-X-C-Motif Receptor 4,CXCR4 ELI

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:8962122, PubMed:9295051, PubMed:9103415).

Involved in the AKT signaling cascade (By similarity).

Plays a role in regulation of cell migration, e.g.

during wound healing.

Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels.

Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity).

Involved in hematopoiesis and in cardiac ventricular septum formation (PubMed:9634237, PubMed:9634238, PubMed:9689100).

Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells (PubMed:9634237).

Involved in cerebellar development.

In the CNS, could mediate hippocampal-neuron survival (PubMed:9634238, PubMed:9689100).

{ECO:0000250|UniProtKB:P61073, ECO:0000269|PubMed:8962122, ECO:0000269|PubMed:9103415, ECO:0000269|PubMed:9295051, ECO:0000269|PubMed:9634237, ECO:0000269|PubMed:9634238, ECO:0000269|PubMed:9689100}.