Mouse Collagen alpha-2(IV) chain,COL4A2 ELI

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity.

It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis.

Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity.

Ligand for alphavbeta3 and alphavbeta5 integrins.