Mouse Collectin-11, COLEC11 ELI

Lectin that plays a role in innate immunity, apoptosis and embryogenesis.

Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope.

Primarily recognizes the terminal disaccharide of the glycan.

Also recognizes a subset of fucosylated glycans and lipopolysaccharides.

Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1.

Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding.

Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis.