Mouse CREB Regulated Transcription Coactivator 3,CRTC3 ELI

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348, PubMed:30611118).

Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348).

Acts independently of CREB1 'Ser-133' phosphorylation (By similarity).

Enhances the interaction of CREB1 with TAF4 (By similarity).

Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR (By similarity).

Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).

{ECO:0000250|UniProtKB:Q6UUV7, ECO:0000269|PubMed:29211348, ECO:0000269|PubMed:30611118}.