Mouse Cub Domain-Containing Protein 1, Cdcp1 Primacu™ ELI
3,970.00 ₪
CDCP1 contains three extracellular CUB domains.
It is a putative stem cell marker that is highly expressed in some human cancer cells and both, typical and atypical (cancerous) colons.
It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1.
It also interacts with SRC and PRKCG/protein kinase C gamma.
CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration.
It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein.
Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR.
It may be involved in cell adhesion and cell matrix association.
It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation.
It has been taken as a novel marker for leukemia diagnosis and immature hematopoietic stem cell subsets.
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