Mouse Cyclin-dependent kinase inhibitor 1,CDKN1A;P21 ELI
3,140.00 ₪
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage.
Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.
Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1.
At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (PubMed:25329316).
Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (By similarity).
Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (By similarity).
{ECO:0000250|UniProtKB:P38936, ECO:0000269|PubMed:25329316}.
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