Mouse Disintegrin and metalloproteinase domain-containing protein 17,ADAM17 ELI

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form.

Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface.

Plays a role in the proteolytic processing of ACE2 (By similarity).

Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:10799547, PubMed:11108241).

Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT) (PubMed:10882063).

Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain (PubMed:12907434).

Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (PubMed:17245433).

Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R (By similarity).

{ECO:0000250|UniProtKB:P78536, ECO:0000269|PubMed:10799547, ECO:0000269|PubMed:10882063, ECO:0000269|PubMed:11108241, ECO:0000269|PubMed:12907434, ECO:0000269|PubMed:17245433}.