Mouse DNA (cytosine-5)-methyltransferase 3A,DNMT3A ELI

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477).

DNA methylation is coordinated with methylation of histones (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477).

It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477).

May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (PubMed:18823905).

Plays a role in paternal and maternal imprinting (PubMed:15215868).

Required for methylation of most imprinted loci in germ cells (PubMed:15215868).

Acts as a transcriptional corepressor for ZBTB18 (PubMed:11350943).

Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (PubMed:20547484).

Can actively repress transcription through the recruitment of HDAC activity (PubMed:11350943).

Also has weak auto-methylation activity on Cys-706 in absence of DNA (PubMed:21481189).

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