Mouse DNA Damage-inducible Transcript 3 Protein, DDIT3 ELI

DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene.

It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors.

The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, preventing their DNA binding activity.

The protein is implicated in adipogenesis and erythropoiesis, and has an important role in the cell's stress response.