Mouse DNA Replication Licensing Factor Mcm2, MCM2 ELI

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.

The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit.

The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Required for the entry in S phase and for cell division.

Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis.