Mouse Ectodysplasin-A, EDA ELI

Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs.

Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R.

Isoform TAA binds only to the receptor EDAR, while isoform TA-A2 binds exclusively to the receptor EDA2R (By similarity). May also play a role in cell adhesion (PubMed:10534613). Isoform TAA binds only to the receptor EDAR, while isoform TA-A2 binds exclusively to the receptor EDA2R. Isoform TA-A2 binds exclusively to the receptor EDA2R.