Mouse Ectonucleotide pyrophosphatase;phosphodiesterase family member 2,ENPP2;Aut

Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids (PubMed:17208043, PubMed:28414242, PubMed:27780639).

Major substrate is lysophosphatidylcholine (PubMed:17208043, PubMed:27780639).

Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility.

Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP (PubMed:18175805).

Involved in several motility-related processes such as angiogenesis and neurite outgrowth.

Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation.

Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein.

May have a role in induction of parturition (By similarity).

Possible involvement in cell proliferation and adipose tissue development (Probable).

Tumor cell motility-stimulating factor.

Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity).

Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity).

{ECO:0000250|UniProtKB:Q13822, ECO:0000269|PubMed:17208043, ECO:0000269|PubMed:18175805, ECO:0000269|PubMed:21240269, ECO:0000269|PubMed:27780639, ECO:0000269|PubMed:28414242, ECO:0000305|PubMed:15700135}.