Mouse Elav-like Protein 1, ELAVL1 ELI

RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability.

Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (PubMed: 24394384).

Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs.

Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs.

In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs.

Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (By similarity).

With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A.

Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity.

May also bind with ZNF385A the CCNB1 mRNA (PubMed: 21402775).

Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed: 27616329).