Mouse Epidermal Growth Factor Receptor, EGFR ELI

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed: 8404850).

Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF.

Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues.

The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades.

Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules.

May also activate the NF-kappa-B signaling cascade.

Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling.

Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (By similarity).

Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (By similarity).

Plays a role in enhancing learning and memory performance (PubMed: 20639532).