Mouse Filamin-A, FLNA ELI
3,140.00 ₪
Actin binding protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins.
Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins (By similarity).
Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate.
Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.
Involved in ciliogenesis.
Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs (PubMed: 17172441).
Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (PubMed: 20713593).
During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed: 25358863).
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