Mouse Fractalkine,FKN;CX3CL1 ELI

Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1 (PubMed:10187784, PubMed:18971423).

The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:10382755, PubMed:9177350, PubMed:10187784, PubMed:18971423).

Regulates leukocyte adhesion and migration processes at the endothelium (PubMed:10382755, PubMed:9177350).

Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner (By similarity).

In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins (By similarity).

In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (By similarity).

{ECO:0000250|UniProtKB:P78423, ECO:0000269|PubMed:10187784, ECO:0000269|PubMed:10382755, ECO:0000269|PubMed:18971423, ECO:0000269|PubMed:9177350}.; [Processed fractalkine]: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils.

{ECO:0000250|UniProtKB:P78423}.; [Fractalkine]: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells.

{ECO:0000250|UniProtKB:P78423}.