Mouse Fructose-1,6-bisphosphatase 1,FBP1 ELI

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis.

Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells.

Appears to modulate glycerol gluconeogenesis in liver.

Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

{ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:20719858}.