Mouse Galectin 8, GAL8 ELI

Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy.

Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture.

Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52.

Required to restrict infection of bacterial invasion such as S.typhimurium.

Also required to restrict infection of Picornaviridae viruses.

Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.