Mouse glucocorticoid receptor,Nr3c1 ELI

Receptor for glucocorticoids (GC).

Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors.

Affects inflammatory responses, cellular proliferation and differentiation in target tissues.

Involved in chromatin remodeling (PubMed:10678832).

Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity).

Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546).

{ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:10678832, ECO:0000269|PubMed:15037546}.; [Isoform 1]: Has transcriptional activation and repression activity (By similarity).

Mediates glucocorticoid-induced apoptosis (By similarity).

Promotes accurate chromosome segregation during mitosis (PubMed:25847991).

May act as a tumor suppressor (PubMed:25847991).

May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (PubMed:21994940).

{ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:21994940, ECO:0000269|PubMed:25847991}.; [Isoform 3]: Acts as a dominant negative inhibitor of isoform 1 (PubMed:20660300).

Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (By similarity).

Loses this transcription modulator function on its own (By similarity).

Has no hormone-binding activity (PubMed:20660300).

May play a role in controlling glucose metabolism by maintaining insulin sensitivity (PubMed:20660300).

Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (By similarity).

Directly regulates STAT1 expression in isoform Alpha-independent manner (By similarity).

{ECO:0000250|UniProtKB:P04150, ECO:0000269|PubMed:20660300}.