Mouse Heparan Sulfate Glucosamine 3-O-sulfotransferase 1, HS3ST1 ELI

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan.

Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact).

This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site.