Mouse Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate, HGS ELI

Involved in intracellular signal transduction mediated by cytokines and growth factors.

When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF.

Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin.

May concentrate ubiquitinated receptors within clathrin-coated regions.

Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex).

The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

May contribute to the efficient recruitment of SMADs to the activin receptor complex.

Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.