Mouse Indian Hedgehog,IHH ELI

Intercellular signal essential for a variety of patterning events during development.

Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes.

Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones.

Induces the expression of parathyroid hormone-related protein (PTHRP).