Mouse Inducible T-cell Costimulator, ICOS ELI

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.

Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens.

Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10.

Prevents the apoptosis of pre-activated T-cells.

Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).