Mouse Inositol Polyphosphate-4-Phosphatase type I 107 kDa,INPP4A ELI
3,140.00 ₪
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PubMed:20463662).
Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity).
Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:11087841, PubMed:19325558).
May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (PubMed:20463662).
{ECO:0000250|UniProtKB:Q62784, ECO:0000269|PubMed:11087841, ECO:0000269|PubMed:19325558, ECO:0000269|PubMed:20463662}.
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