Mouse Integrin Beta-1, ITGB1 ELI

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen.

Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen.

Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin.

Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin.

Integrin alpha-5/beta-1 is a receptor for fibrinogen.

Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin.

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (PubMed: 10634791).

Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1.

Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin.

It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.

Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4.

Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion.

Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.

Integrin alpha-V/beta-1 is a receptor for vitronectin.

Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands.

When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition (PubMed: 12941630).

Involved in promoting endothelial cell motility and angiogenesis (PubMed: 15181153).

Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules (PubMed: 21768292).

May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1.

Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation.

Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (PubMed: 18804435).

ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (By similarity).

ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity).

ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity).

ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity).

ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity).

[Isoform 2]: Isoform 2 displaces isoform 1 in striated muscles.