Mouse Integrin Beta-3, ITGB3 ELI

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, Matrix Metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor.

Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin.

Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands.

Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain.

Following activation integrin alpha-IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen.

This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surfaces.

Fibrinogen binding enhances SELP expression in activated platelets (PubMed: 19332769).

ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling.

ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling.

ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling.

ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (By similarity).

ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity).

ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity).

ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (By similarity).

ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity).

ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity).

In brain, plays a role in synaptic transmission and plasticity (PubMed: 29038237, PubMed: 18549786).

Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin (PubMed: 29038237).

Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (PubMed: 18549786).

ITGAV:ITGB3 act as a receptor for CD40LG (By similarity).