Mouse Interferon Regulatory Factor 4, IRF4 ELI

Transcriptional activator.

Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter.

Binds the immunoglobulin lambda light chain enhancer, together with PU.1.

Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.

Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.