Mouse Interleukin-1 Alpha, Il1a Primacu™ ELI
3,970.00 ₪
IL-1 alpha is a member of the interleukin 1 cytokine family.
Cytokines are proteinaceous signaling compounds that are major mediators of the immune response.
They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases.
Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems.
Cytokines can be classified into two groups: pro- and anti-inflammatory.
Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6, and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells.
Anti-inflammatory cytokines, including IL-10, IL-4, IL-13, and IL-5, are synthesized from Th2 immune cells.
IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis.
It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis.
IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.
Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
Quantity