Mouse Interleukin 1 Receptor 1,IL1R1 ELI

Receptor for IL1A, IL1B and IL1RN.

After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways.

Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits.

Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity).

{ECO:0000250|UniProtKB:P14778}.; [Isoform 2]: Unable to mediate canonical IL-1 signaling.

Cooperates with IL1RAP isoform 3 to mediate IL1B-induced neuronal activity including IL1B-potentiated NMDA-induced calcium influx mediated by Akt kinase activation.

{ECO:0000269|PubMed:22778412}.