Mouse Interleukin-1 Receptor Type 1, Il1r1 Primacu™ ELI

Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor.

IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family.

This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA).

IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses.

This protein has been characterized by pharmacological and molecular techniques in the mouse brain.

The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue.

The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects.

In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation.

In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found.

However, the regulation of its expression is distinct from IL-1R1/CD121a.

The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.