Mouse Interleukin 16, IL-16 ELI
3,140.00 ₪
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils.
Primes CD4+ T-cells for IL-2 and IL-15 responsiveness.
Also induces T-lymphocyte expression of interleukin 2 receptor.
Ligand for CD4.
Isoform 1 may act as a scaffolding protein that anchors ion Channels in the membrane.
Isoform 2 is involved in cell cycle progression in T-cells.
Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene.
May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
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