Mouse Interleukin 21, IL-21 ELI
3,140.00 ₪
Cytokine with immunoregulatory activity.
May promote the transition between innate and adaptive immunity.
Induces the production of IgG(1) and IgG(3) in B-cells (PubMed: 15100251).
Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers.
Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (PubMed: 23045607).
May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15 (PubMed: 11970879).
May regulate proliferation of mature B- and T-cells in response to activating stimuli.
In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity).
During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (PubMed: 12893770).
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