Mouse Isocitrate Dehydrogenase, Nadp, Cytoplasmic, IDH1 ELI

Isocitrate dehydrogenase 1 (NADP+), soluble is an enzyme that in humans is encoded by the IDH1 gene on chromosome 2.

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate.

These enzymes belong to two distinct subclasses, one of which uses NAD+ as the electron acceptor and the other NADP+.

Five isocitrate dehydrogenases have been reported: three NAD+-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP+-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic.

Each NADP+-dependent isozyme is a homodimer.

The protein encoded by this gene is the NADP+-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes.

It contains the PTS-1 peroxisomal targeting signal sequence.

The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2,4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid.

The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Alternatively spliced transcript variants encoding the same protein have been found for this gene.