Mouse Kremen protein 1,KREMEN1 ELI
3,140.00 ₪
Receptor for Dickkopf proteins.
Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670).
In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane (By similarity).
Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1 (PubMed:26206087).
Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822).
Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification (PubMed:27550540).
{ECO:0000250|UniProtKB:Q90Y90, ECO:0000269|PubMed:12050670, ECO:0000269|PubMed:18505822, ECO:0000269|PubMed:26206087, ECO:0000269|PubMed:27550540}.
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