Mouse Low Density Lipoprotein Receptor Related Protein 1,LRP1 ELI

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells.

Required for early embryonic development (PubMed:1423604).

Involved in cellular lipid homeostasis.

Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors.

Acts as an alpha-2-macroglobulin receptor (By similarity).

Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178).

May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (By similarity).

{ECO:0000250|UniProtKB:Q07954, ECO:0000269|PubMed:1423604, ECO:0000269|PubMed:32296178}.; (Microbial infection) Functions as a receptor for Vibrio cholerae cholix toxin and for Pseudomonas aeruginosa exotoxin A.

{ECO:0000269|PubMed:1618748, ECO:0000269|PubMed:18276581}.