Mouse Macrosialin, CD68 ELI

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions.

Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites.

Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.