Mouse Metabotropic Glutamate Receptor 6, GRM6 ELI

G-protein coupled receptor for glutamate.

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.

Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca2+ uptake.

Required for normal vision.