Mouse Nerve growth factor,NGF ELI
3,140.00 ₪
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:20036257).
Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:22649032).
The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse (PubMed:22155786).
In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (PubMed:20036257).
Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity).
Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer (PubMed:22649032, PubMed:26144237).
The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (PubMed:22649032).
{ECO:0000250|UniProtKB:P01138, ECO:0000269|PubMed:20036257, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:22649032, ECO:0000269|PubMed:26144237}.
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