Mouse Niemann-Pick C1 protein,NPC1 ELI
3,140.00 ₪
Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:21896731, PubMed:22048958, PubMed:27551080).
Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1.
Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (By similarity).
May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).
{ECO:0000250|UniProtKB:O15118, ECO:0000269|PubMed:21896731, ECO:0000269|PubMed:22048958, ECO:0000269|PubMed:27551080, ECO:0000305}.
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