Mouse Phosphate-regulating neutral endopeptidase PHEX,PHEX ELI

Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (By similarity).

Cleaves ASARM peptides between Ser and Glu or Asp residues (By similarity).

Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:11159866, PubMed:18597632, PubMed:26051469).

Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:26051469).

Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (By similarity).

{ECO:0000250|UniProtKB:P78562, ECO:0000269|PubMed:11159866, ECO:0000269|PubMed:26051469, ECO:0000305|PubMed:18597632}.