Mouse Potassium channel subfamily K member 2,KCNK2 ELI

Ion channel that contributes to passive transmembrane potassium transport.

Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner.

In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2 (PubMed:24496152).

In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (PubMed:24496152).

{ECO:0000269|PubMed:10321245, ECO:0000269|PubMed:16636285, ECO:0000269|PubMed:24496152, ECO:0000269|PubMed:9003761}.