Mouse Probable carboxypeptidase PM20D1,PM20D1 ELI
3,140.00 ₪
Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase.
It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction (PubMed:27374330, PubMed:29533650, PubMed:29967167, PubMed:32271712, PubMed:32402239) (Probable).
Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner.
Thereby, this secreted protein may indirectly regulate whole body energy expenditure (PubMed:27374330, PubMed:29967167, PubMed:32271712).
PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles (PubMed:32402239).
{ECO:0000269|PubMed:27374330, ECO:0000269|PubMed:29533650, ECO:0000269|PubMed:29967167, ECO:0000269|PubMed:32271712, ECO:0000269|PubMed:32402239, ECO:0000305|PubMed:31659023}.
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