Mouse Protein FADD,FADD ELI

Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors.

The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation.

Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.

Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

{ECO:0000250|UniProtKB:Q13158}.